RAADfest Sparks First Telomerase Clinical Trial: Hear Dr. Bill Andrews and James Strole

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James Strole, Director of the Coalition for Radical Life Extension, organizer of RAADfest, and Dr. Bill Andrews President of Sierra Sciences, speak on first ever Telomerase human trial targeting Alzheimer’s and aging.

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Announcement Video

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Why we age – the search for youth with Bill Andrews

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For the last 20 years, he’s focused on finding ways to assist in the function of telomere maintenance. As one of the principal discoverers of both the RNA and protein components of human telomerase, he was awarded 2nd place as “United States Inventor of the Year” in 1997. He is also a named inventor on 45 US issued patents on…

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Sunrise Channel 7: Dr Bill Andrews On How To Cure Aging

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It has been proven in extensive laboratory testing to significantly slow down the shortening of our telomeres. (Telomeres? They are the caps on the end of our chromosomes, and as we age, our telomeres shorten. But more on that a little later.) If you look in the mirror and you’re dismayed by the effects of age on your skin –…

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Bill Andrews: Isolating New Telomerase

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Dr. Ed Park of Recharge Biomedical interviews Bill Andrews, PhD. Dr. Andrews is a telomere biologist and CEO of Sierra Sciences. He explains the methodology for isolating telomerase activators and discusses why telomerase gene therapy was wrongly blamed for carcinogenesis. Third of three interviews

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Bill Andrews: On Why Telomerase Doesn’t Cause Cancer

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Dr. Ed Park of Recharge Biomedical interviews telomere scientist, Dr. Bill Andrews at the 2016 AMMG conference. In this first of 1 interview segments, Dr. Andrews explains the origins of the misconception about telomerase causing cancer and why it actually is protective.

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Dr. Bill Andrews: “What’s Real and What’s Not”

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Dr. Bill Andrews, the leading scientist in the field of life extension, a pioneer in telomeres research, and Sierra Sciences CEO, present in People Unlimited’s Spring Celebration 2016, held in Scottsdale, AZ. People Unlimited provides an ongoing program of support, insight, and inspiration to empower you to more fully experience and manifest your true unlimited potential.

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Bill Andrews – Preventing Aging

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William Henry “Bill” Andrews, Ph.D. is an American molecular biologist and gerontologist whose career has centered on searching for a cure for human aging. Andrews is the founder and president of the biotechnology company Sierra Sciences. In 1997, he led the team at Geron Corporation that was the first to successfully identify human telomerase.

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Telemerase Function.

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Harvard Scientists REVERSE Aging In Mice

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Dr. David Sinclair, from Harvard Medical School, and his colleagues reveal their new findings in the latest issue of Science. They focused on an intriguing compound with anti-aging properties called NAD+, short for nicotinamide adenine dinucleotide. It’s been known that younger mice had more of it than older mice and back in 2013, the researchers found that when they boosted…

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Diane Sawyer ABC News: Telomerase Activated in Mice

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Researchers at Harvard-affiliated medical centers genetically manipulated mice to age faster and then used gene therapy to lengthen telomeres — compounds found at the ends of strands of DNA — which reversed age-related problems such as decreased brain function and infertility. Researchers boosted telomerase in the mice cells — which hold 20 pairs of chromosomes — to prevent telomeres from getting…

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Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer.
Bernardes de Jesus B, Vera E, Schneeberger K, Tejera AM, Ayuso E, Bosch F, Blasco MA.
EMBO Mol Med. 2012 Aug;4(8):691-704. doi: 10.1002/emmm.201200245. Epub 2012 May 15.

Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice.
Jaskelioff M, Muller FL, Paik JH, Thomas E, Jiang S, Adams AC, Sahin E, Kost-Alimova M, Protopopov A, Cadiñanos J, Horner JW, Maratos-Flier E, Depinho RA.
Nature. 2011 Jan 6;469(7328):102-6. doi: 10.1038/nature09603. Epub 2010 Nov 28.

Telomeres, cancer, and aging. Altering the human life span.
Banks DA, Fossel M.
JAMA. 1997 Oct 22-29;278(16):1345-8.

Telomerase and the aging cell: implications for human health.
Fossel M.
JAMA. 1998 Jun 3;279(21):1732-5. Review.

Use of Telomere Length as a Biomarker for Aging and Age-Related Disease
Fossel, M.
Curr Tran Geriatr Gerontol Rep (2012) 1: 121. https://doi.org/10.1007/s13670-012-0013-6

The Complexity and Abundance of RNA Transcribed from Restriction Endonuclease Fragments of Euglena Chloroplast DNA During Chloroplast Development.
Rawson, J. R. Y., C. L. Boerma, W. H. Andrews, and C. G. Wilkerson.
Biochemistry 20, 2639-2644. (1981)

Cloning of Chloroplast DNA in Bacterial Plasmid Vectors
Rawson, J. R. Y. and W. H. Andrews.
In Methods in Chloroplast Molecular Biology. ed. M. Edelman, R. B. Hallick, and N. H. Chua. Elsevier/North Holland. 493-506 (1982)

Expression of Cloned Chloroplast DNA in E. coli Minicells
Andrews, W. H. and J. R. Y. Rawson
In Methods in Chloroplast Molecular Biology. ed. M. Edelman, R. B. Hallick, and N. H. Chua. Elsevier/North Holland. 565-571 (1982)

Expression of Cloned Chloroplast DNA from Euglena gracilis in an In Vitro DNA-Dependent Transcription-Translation System Prepared from E. coli.
Andrews, W. H. and J. R. Y. Rawson
Plasmid 8, 148-163 (1982)

Enzymatic Properties of Bovine Prochymosin Synthesized in Escherichia coli.
McCaman, M. T., W. H. Andrews, and J. G. Files
Biotechnology 2, 177-190 (1985)

Characterization of a Surface Antigen of Eimeria-Tenella Sporozoites and Synthesis from a Cloned Complementary DNA in Escherichia-Coli.
Brothers VM, Kuhn I, Paul LS, Gabe JD, Andrews WH, Sias SR, McCaman MT, Dragon EA, Files JG.
Mol Biochem Parasitol 28, 235-248 (1988)

Cloning of the Gene Coding for a Human Receptor for Formyl Peptides Characterization of a Promoter Region and Evidence for Polymorphic Expression.
Perez HD, Holmes R, Kelly E, McClary J, Chou Q, Andrews WH.
Biochemistry 31, 11595-11599 (1992)

Cloning of a cDNA Encoding a Receptor Related to the Formyl Peptide Receptor of Human Neutrophils.
Perez HD, Holmes R, Kelly E, McClary J, Andrews WH.
Gene 118, 303-304 (1992)

Oxidation of a specific methionine in thrombomodulin by activated neutrophil products blocks cofactor activity. A potential rapid mechanism for modulation of coagulation.
Glaser CB; Morser J; Clarke JH; Blasko E; McLean K; Kuhn I; Chang RJ; Lin JH; Vilander L; Andrews WH.
J Clin Invest 90, 2565-73 (1992)

Formyl Peptide Receptor Chimeras Define Domains Involved in Ligand Binding.
Perez HD, Holmes R, Vilander LR, Adams RR, Manzana W, Jolley D, Andrews WH.
J Biol Chem 268, 2292-2295 (1993)

The Short Loop Between EGF-like Domains Four and Five is Critical for Human Thrombomodulin Function.
Clarke JH, Light DR, Blasko E, Parkinson JF, Nagashima M, McLean K, Vilander L, Andrews WH, Morser J, Glaser CB.
J Biol Chem 268, 6309-6315 (1993)

Expression Efficiency of the Human Thrombomodulin-Encoding Gene in Various Vector and Host Systems.
Lin J-H, Wang M, Andrews WH, Wydro R, Morser J.
Gene 147, 287-292 (1994)

Isolation of Extracytoplasmic Proteins from Serpulina hyodysenteriae B204 and Molecular Cloning of the flaB1 Gene Encoding a 38-Kilodalton Flagellar Protein.
Gabe JD, Chang R-J, Slomiany R, Andrews WH, McCaman MT.
Infection and Immunity 63, 142-148 (1994)

Human Formyl Peptide Receptor Ligand Binding Domain(s) – Studies Using an Improved Mutagenesis/Expression Vector Reveal a Novel Mechanism for the Regulation of Receptor Occupancy.
Perez DH, Vilander L, Andrews WH, Holmes R.
J Biol Chem 269, 22485-22487 (1994)

Modulation of Glycosaminoglycan Addition in Naturally Expressed and Recombinant Human Thrombomodulin.
Lin JH, McLean K, Morser J, Young TA, Wydro RM, Andrews WH, Light DR.
J Biol Chem 269, 25021-25030 (1994)

Cataloging Altered Gene Expression in Young and Senescent Cells using Enhanced Differential Display.
Linskens MH, Feng J, Andrews WH, Enlow BE, Saati SM, Tonkin LA, Funk WD, Villeponteau B.
Nucleic Acids Research 23, 3244-3251 (1995).

The RNA Component of Human Telomerase
Feng J, Funk WD, Wang S-S, Weinrich SL, Avilion AA, Chiu C-P, Adams RA, Chang E, Allsopp, RC, Yu J, Le S, West MD, Harley CB, Andrews WH, Greider CW, Villeponteau B.
Science 269, 1236-1241 (1995).

Telomerase Catalytic Subunit Homologs From Fission Yeast and Human.
Nakamura TM, Morin GB, Chapman KB, Weinrich SL, Andrews WH, Lingner J, Harley CB, Cech TR.
Science 277, 955-959 (1997).

Reconstitution of Human Telomerase With the Template RNA Component hTR and the Catalytic Protein Subunit hTRT.
Weinrich SL, Pruzan R, Ma L, Ouellette M, Tesmer VM, Holt SE, Bodnar AG, Lichtsteiner S, Kim NW, Trager JB, Taylor RD, Carlos R, Andrews WH, Wright WE, Shay JW, Harley CB, Morin GB.
Nature Genetics 17, 498-502 (1997)

Spontaneous reversal of the developmental aging of normal human cells following transcriptional reprogramming.
Vaziri H, Chapman KB, Guigova A, Teichroeb J, Lacher MD, Sternberg H, Singec I, Briggs L, Wheeler J, Sampathkumar J, Gonzalez R, Larocca D, Murai J, Snyder E, Andrews WH, Funk WD, West MD.
Regen Med. 5 (3):345-63 (2010).

RNAi screen for telomerase reverse transcriptase transcriptional regulators identifies 
HIF1alpha as critical for  telomerase function in murine embryonic stem cells.
Coussens M, Davy P, Brown L, Foster C, Andrews WH, Nagata M, Allsopp R.
Proc Natl Acad Sci U S A. 107(31):13842-7 (2010).

A Natural Product Telomerase Activator As Part of a Health Maintenance Program.
Harley CB, Liu W, Blasco M, Vera E, Andrews WH, Briggs LA, Raffaele JM.
Rejuvenation Res. 14(1):45-56 (2010)

Antiproliferative small molecule inhibitors of transcription factor LSF reveal oncogene addiction to LSF in hepatocellular carcinoma
Grant TJ, Bishop JA, Christadore LM, Barot G, Chin HG, Woodson S, Kavouris J, Siddiq A, Gredler R, Shen X, Sherman J, Meehan T, Fitzgerald KJ, Pradhan S, Briggs LA, Andrews WH, Sarkar D, Schaus SE, Hansen U.
Proc Natl Acad Sci U S A. (submitted for publication 12/30/2011, accepted 2/2/2012).

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